An L-Band, Circularly Polarized, Dual-Feed, Cavity-Backed Annular Slot Antenna with Wide-Angle Coverage

An L-band, circularly polarized, dual-feed, cavity-backed annular slot antenna has been investigated. The investigations comprise parametric studies of design parameters and measurements with different ground planes. The antenna has an impedance bandwidth of 6% around 1.59 GHz and a maximum directivity of about 7 dBi

A short comment on the early development of Odense

In a recent overview of the material from eighth to twelfth century Odense, Runge and Henriksen propose to move the date of the town’s foundation by a hundred years, to the early tenth century. In this brief comment we challenge their interpretation of the earliest Odense, and point to some problems with their definition of what constitutes towns and proto-towns, as well as the analysis of the material they present

Marine DNA polymerases as tools for next generation molecular diagnostics solutions

Globally, there is a high demand to monitor and diagnose critical infectious diseases. Current molecular diagnostic tests require long “sample in - answer out” time and expensive equipment. Isothermal Nucleic Acid Amplification Technology (INAAT) is an enabling technology possibly offering rapid, sensitive and specific molecular diagnosis of infectious diseases. However, the implementation of INAAT into Point of Care diagnostic platforms are halted due to a very limited selection of suitable enzymes, i.e. polymerases, performing at ambient temperatures. The overall goal with the project is to bring a panel of new and improved polymerase enzymes to market for use in next generation INAAT molecular diagnostic platforms and other potential application areas, e.g. next-generation sequencing and single-cell genomics. We have identified and characterized a large selection of polymerase enzymes based on marine bioprospecting of the arctic and subarctic region. These act as starting point for the development of 2nd generation isothermal amplification polymerases. Through use of our highly versatile molecular evolution library, combined with rational design studies, tailor-made enzymes for various application areas will be developed. This project emphasizes on early market feedback to confirm relevance and applicability and to ensure that enzymes are developed according to customer needs

Biased and g protein-independent signaling of chemokine receptors

Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three distinct forms: ligand bias, receptor bias, and tissue or cell bias, where it is mediated by different ligands (on the same receptor), different receptors (with the same ligand) or different tissues or cells (for the same ligand-receptor pair). Most often biased signaling is differentiated into G protein-dependent and β-arrestin-dependent signaling. Yet, it may also cover signaling differences within these groups. Moreover, it may not be absolute, i.e. full versus no activation. Here we discuss biased signaling in the chemokine system, including the structural basis for biased signaling in chemokine receptors, as well as in class A 7TM receptors in general. This includes overall helical movements and the contributions of micro-switches based on recently published 7TM crystals and molecular dynamics studies. All three forms of biased signaling are abundant in the chemokine system. This challenges our understanding of classic redundancy inevitably ascribed to this system, where multiple chemokines bind to the same receptor and where a single chemokine may bind to several receptors – in both cases with the same functional outcome. The ubiquitous biased signaling confer a hitherto unknown specificity to the chemokine system with a complex interaction pattern that is better described as promiscuous with context-defined roles and different functional outcomes in a ligand-, receptor- or cell/tissue-defined manner. As the low number of successful drug development plans implies, there are great difficulties in targeting chemokine receptors; in particular with regard to receptor antagonists as anti-inflammatory drugs. Un-defined and putative non-selective targeting of the complete cellular signaling system could be the underlying cause of lack of success. Therefore, biased ligands could be the solution

Disruption som konkurrencestatsideal: Udbredelsen af disruptionideen i Danmark

På baggrund af et bredt kildemateriale bestående af rapporter, avisartikler og bøger analyserer denne artikel disruptionideens udbredelse i Danmark. Artiklen bidrager til konkurrencestatens idéhistorie ved at vise, hvordan disruptionideen i det seneste årti er blevet et nyt buzzword inden for innovations-, udviklings- og entreprenørskabstænkningen, som rummer løfter om vækst og konkurrencedygtighed i fremtiden. Mere konkret viser artiklen med udgangspunkt i Michael Freedens ideologiforståelse, hvordan disruption er blevet mobiliseret som et ideal, der skal hjælpe erhvervslivet, den offentlige sektor og individet på den rette vej ind i fremtiden

A biomechanical analysis of wide, medium, and narrow grip width effects on kinematics, horizontal kinetics, and muscle activity on the sticking region in recreationally trained males during 1-RM bench pressing

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